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Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors

[Image: see text] Breast cancer (BC) is the most diffused cancer type in women and the second leading cause of death among the female population. Effective strategies to fight estrogen responsive (ER+) BC, which represents 70% of all BC cases, rely on estrogen deprivation, via the inhibition of the...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Caciolla, Jessica, Spinello, Angelo, Martini, Silvia, Bisi, Alessandra, Zaffaroni, Nadia, Gobbi, Silvia, Magistrato, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236249/
https://ncbi.nlm.nih.gov/pubmed/32435378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00591
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