Progression and Classification of Granular Osmiophilic Material (GOM) Deposits in Functionally Characterized Human NOTCH3 Transgenic Mice

CADASIL is a NOTCH3-associated cerebral small vessel disease. A pathological ultrastructural disease hallmark is the presence of NOTCH3-protein containing deposits called granular osmiophilic material (GOM), in small arteries. How these GOM deposits develop over time and what their role is in diseas...

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發表在:Transl Stroke Res
Main Authors: Gravesteijn, Gido, Munting, Leon P., Overzier, Maurice, Mulder, Aat A., Hegeman, Ingrid, Derieppe, Marc, Koster, Abraham J., van Duinen, Sjoerd G., Meijer, Onno C., Aartsma-Rus, Annemieke, van der Weerd, Louise, Jost, Carolina R., van den Maagdenberg, Arn M. J. M., Rutten, Julie W., Lesnik Oberstein, Saskia A. J.
格式: Artigo
語言:Inglês
出版: Springer US 2019
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7235067/
https://ncbi.nlm.nih.gov/pubmed/31667734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12975-019-00742-7
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