Modulation of the Cardiac Sodium Channel Na(V)1.5 Peak and Late Currents by NAD(+) Precursors

RATIONALE: The cardiac sodium channel Na(V)1.5, encoded by SCN5A, produces the rapidly inactivating depolarizing current I(Na) that is responsible for the initiation and propagation of the cardiac action potential. Acquired and inherited dysfunction of Na(V)1.5 results in either decreased peak I(Na)...

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Publicat a:J Mol Cell Cardiol
Autors principals: Matasic, Daniel S., Yoon, Jin-Young, McLendon, Jared M., Mehdi, Haider, Schmidt, Mark S., Greiner, Alexander M., Quinones, Pravda, Morgan, Gina M., Boudreau, Ryan L., Irani, Kaikobad, Brenner, Charles, London, Barry
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7234910/
https://ncbi.nlm.nih.gov/pubmed/32209328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2020.01.013
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