Notoginsenoside R1 upregulates miR-221-3p expression to alleviate ox-LDL-induced apoptosis, inflammation, and oxidative stress by inhibiting the TLR4/NF-κB pathway in HUVECs

Atherosclerosis (AS) is a common vascular disease, which can cause apoptosis of vascular endothelial cells. Notoginsenoside R1 (NGR1) is considered an anti-AS drug. MicroRNAs (miRNAs) are believed to play a vital role in cell apoptosis and angiogenesis. This study aimed to explore the mechanism of N...

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Détails bibliographiques
Publié dans:Braz J Med Biol Res
Auteurs principaux: Zhu, Lingbo, Gong, Xinyan, Gong, Jianping, Xuan, Yungang, Fu, Ting, Ni, Shimao, Xu, Lei, Ji, Ningning
Format: Artigo
Langue:Inglês
Publié: Associação Brasileira de Divulgação Científica 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233198/
https://ncbi.nlm.nih.gov/pubmed/32401923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1414-431X20209346
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