Influence of Genetic Admixture Components on CYP3A5*3 Allele-Associated Hypertension in Amerindian Populations From Northwest Mexico

CYP3A5 metabolizes endogenous substrates and ~30% of prescription drugs. The CYP3A5 gene contains an active CYP3A5*1 allele, and a non-functional version, the CYP3A5*3 (rs776746), with consequences for drug therapeutic responses and side effects. Both CYP3A5*1 and *3 have been associated with hypert...

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Опубликовано в: :Front Pharmacol
Главные авторы: Galaviz-Hernández, Carlos, Lazalde-Ramos, Blanca P., Lares-Assef, Ismael, Macías-Salas, Alejo, Ortega-Chavez, Margarita A., Rangel-Villalobos, Héctor, Sosa-Macías, Martha
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7232668/
https://ncbi.nlm.nih.gov/pubmed/32477124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00638
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