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Rapid Quantification of Protein-Ligand Binding via (19)F NMR Lineshape Analysis
Fluorine incorporation is ideally suited to many NMR techniques, and incorporation of fluorine into proteins and fragment libraries for drug discovery has become increasingly common. Here, we use one-dimensional (19)F NMR lineshape analysis to quantify the kinetics and equilibrium thermodynamics for...
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| Udgivet i: | Biophys J |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Biophysical Society
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7231920/ https://ncbi.nlm.nih.gov/pubmed/32348722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.03.031 |
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