CDH1 Mutation Distribution and Type Suggests Genetic Differences between the Etiology of Orofacial Clefting and Gastric Cancer

Pathogenic variants in CDH1, encoding epithelial cadherin (E-cadherin), have been implicated in hereditary diffuse gastric cancer (HDGC), lobular breast cancer, and both syndromic and non-syndromic cleft lip/palate (CL/P). Despite the large number of CDH1 mutations described, the nature of the pheno...

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Vydáno v:Genes (Basel)
Hlavní autoři: Selvanathan, Arthavan, Nixon, Cheng Yee, Zhu, Ying, Scietti, Luigi, Forneris, Federico, Moreno Uribe, Lina M., Lidral, Andrew C., Jezewski, Peter A., Mulliken, John B., Murray, Jeffrey C., Buckley, Michael F., Cox, Timothy C., Roscioli, Tony
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7231129/
https://ncbi.nlm.nih.gov/pubmed/32260281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11040391
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