Flow-induced Shear Stress Confers Resistance to Carboplatin in an Adherent Three-Dimensional Model for Ovarian Cancer: A Role for EGFR-Targeted Photoimmunotherapy Informed by Physical Stress

A key reason for the persistently grim statistics associated with metastatic ovarian cancer is resistance to conventional agents, including platinum-based chemotherapies. A major source of treatment failure is the high degree of genetic and molecular heterogeneity, which results from significant und...

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Publicat a:J Clin Med
Autors principals: Nath, Shubhankar, Pigula, Michael, Khan, Amjad P., Hanna, William, Ruhi, Mustafa Kemal, Dehkordy, Farzaneh Mahmoodpoor, Pushpavanam, Karthik, Rege, Kaushal, Moore, Kaitlin, Tsujita, Yujiro, Conrad, Christina, Inci, Fatih, del Carmen, Marcela G., Franco, Walfre, Celli, Jonathan P., Demirci, Utkan, Hasan, Tayyaba, Huang, Huang-Chiao, Rizvi, Imran
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7230263/
https://ncbi.nlm.nih.gov/pubmed/32231055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm9040924
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