Загрузка...
Amyloid assembly is dominated by misregistered kinetic traps on an unbiased energy landscape
Atomistic description of protein fibril formation has been elusive due to the complexity and long time scales of the conformational search. Here, we develop a multiscale approach combining numerous atomistic simulations in explicit solvent to construct Markov State Models (MSMs) of fibril growth. Th...
Сохранить в:
| Опубликовано в: : | Proc Natl Acad Sci U S A |
|---|---|
| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2020
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7229673/ https://ncbi.nlm.nih.gov/pubmed/32345723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911153117 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|