Chronic Ethanol Feeding in Mice Decreases Expression of Genes for Major Structural Bone Proteins in a Nox4-Independent Manner

Bone loss in response to alcohol intake has previously been hypothesized to be mediated by excessive production of reactive oxygen species via NADPH oxidase (Nox) enzymes. Nox4 is one of several Nox enzymes expressed in bone. We investigated the role of Nox4 in the chondro-osteoblastic lineage of th...

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Опубликовано в: :J Pharmacol Exp Ther
Главные авторы: Pedersen, Kim B., Osborn, Michelle L., Robertson, Alex C., Williams, Ashlee E., Watt, James, Denys, Alexandra, Schröder, Katrin, Ronis, Martin J.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2020
Предметы:
Toxicology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228502/
https://ncbi.nlm.nih.gov/pubmed/32213546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.264374
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