Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice

The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tissue regeneration. HIF-1 is negatively controlled by O(2)-dependent prolyl hydroxylases with a predominant role of prolyl hydroxylase 2 isoform (Phd2). Transgenic mice, hypomorphic for this isoform, accumulate more...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Settelmeier, Stephan, Schreiber, Timm, Mäki, Joni, Byts, Nadiya, Koivunen, Peppi, Myllyharju, Johanna, Fandrey, Joachim, Winning, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228053/
https://ncbi.nlm.nih.gov/pubmed/32413092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0233261
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