Effect of CRISPR/Cas9-Mediated PD-1-Disrupted Primary Human Third-Generation CAR-T Cells Targeting EGFRvIII on In Vitro Human Glioblastoma Cell Growth

Glioblastoma (GBM), which is the most common malignant brain tumor, is resistant to standard treatments. Immunotherapy might be a promising alternative for the treatment of this cancer. Chimeric antigen receptor (CAR) is an artificially modified fusion protein that can be engineered to direct the sp...

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Vydáno v:Cells
Hlavní autoři: Nakazawa, Tsutomu, Natsume, Atsushi, Nishimura, Fumihiko, Morimoto, Takayuki, Matsuda, Ryosuke, Nakamura, Mitsutoshi, Yamada, Shuichi, Nakagawa, Ichiro, Motoyama, Yasushi, Park, Young-Soo, Tsujimura, Takahiro, Wakabayashi, Toshihiko, Nakase, Hiroyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227242/
https://ncbi.nlm.nih.gov/pubmed/32316275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9040998
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