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Generation of gene-corrected functional osteoclasts from osteopetrotic induced pluripotent stem cells
BACKGROUND: Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by non-functional osteoclasts and a fatal outcome early in childhood. About 50% of patients have mutations in the TCIRG1 gene. METHODS: IMO iPSCs were generated from a patient carrying a homozygous c...
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| Publicado no: | Stem Cell Res Ther |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7227215/ https://ncbi.nlm.nih.gov/pubmed/32414402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-01701-y |
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