Sex-Specific Regulation of miR-29b in the Myocardium Under Pressure Overload is Associated with Differential Molecular, Structural and Functional Remodeling Patterns in Mice and Patients with Aortic Stenosis

Pressure overload in patients with aortic stenosis (AS) induces an adverse remodeling of the left ventricle (LV) in a sex-specific manner. We assessed whether a sex-specific miR-29b dysregulation underlies this sex-biased remodeling pattern, as has been described in liver fibrosis. We studied mice w...

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Publicat a:Cells
Autors principals: García, Raquel, Salido-Medina, Ana B., Gil, Aritz, Merino, David, Gómez, Jenny, Villar, Ana V., González-Vílchez, Francisco, Hurlé, María A., Nistal, J. Francisco
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226763/
https://ncbi.nlm.nih.gov/pubmed/32235655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9040833
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