Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Mitotane, the standard treatment for ACC, impairs adrenocortical steroid biosynthesis and cholesterol metabolism. In the H295R cell line, a standard ACC in vitro model, mitotane was previously reported to enhance the production of...

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Udgivet i:Cells
Main Authors: Germano, Antonina, Rossin, Daniela, Leoni, Valerio, Iaia, Noemi, Saba, Laura, Basile, Vittoria, Puglisi, Soraya, Caccia, Claudio, Poli, Giuseppe, Biasi, Fiorella, Terzolo, Massimo
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226725/
https://ncbi.nlm.nih.gov/pubmed/32260362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9040885
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