Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma

Uveal melanoma (UM) has well-characterised somatic copy number alterations (SCNA) in chromosomes 1, 3, 6 and 8, in addition to mutations in GNAQ, GNA11, CYSLTR2, PLCB4, BAP1, SF3B1 and EIF1AX, most being linked to metastatic-risk. To gain further insight into the molecular landscape of UM, we design...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Thornton, Sophie, Coupland, Sarah E., Olohan, Lisa, Sibbring, Julie S., Kenny, John G., Hertz-Fowler, Christiane, Liu, Xuan, Haldenby, Sam, Heimann, Heinrich, Hussain, Rumana, Kipling, Natalie, Taktak, Azzam, Kalirai, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226611/
https://ncbi.nlm.nih.gov/pubmed/32340176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12041039
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