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The Core-Clock Gene NR1D1 Impacts Cell Motility In Vitro and Invasiveness in a Zebrafish Xenograft Colon Cancer Model

Malfunctions of circadian clock trigger abnormal cellular processes and influence tumorigenesis. Using an in vitro and in vivo xenograft model, we show that circadian clock disruption via the downregulation of the core-clock genes BMAL1, PER2, and NR1D1 impacts the circadian phenotype of MYC, WEE1,...

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Bibliografski detalji
Izdano u:Cancers (Basel)
Glavni autori: Basti, Alireza, Fior, Rita, Yalҫin, Müge, Póvoa, Vanda, Astaburuaga, Rosario, Li, Yin, Naderi, Julian, Godinho Ferreira, Miguel, Relógio, Angela
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226575/
https://ncbi.nlm.nih.gov/pubmed/32244760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12040853
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