Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2

Aberrant regulation of the cell cycle is a typical feature of all forms of cancer. In head and neck squamous cell carcinoma (HNSCC), it is often associated with the overexpression of cyclin D1 (CCND1). However, it remains unclear how CCND1 expression changes between tumor and normal tissues and whet...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Novotný, Jiří, Bandúrová, Veronika, Strnad, Hynek, Chovanec, Martin, Hradilová, Miluše, Šáchová, Jana, Šteffl, Martin, Grušanović, Josipa, Kodet, Roman, Pačes, Václav, Lacina, Lukáš, Smetana, Karel, Plzák, Jan, Kolář, Michal, Vomastek, Tomáš
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226528/
https://ncbi.nlm.nih.gov/pubmed/32224897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12040792
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