Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation

Background: Renal cell carcinoma (RCC) displays a glycolytic phenotype (Warburg effect). Increased lactate production, impacting on tumor biology and microenvironment modulation, has been implicated in epigenetic mechanisms’ regulation, leading to histone deacetylases inhibition. Thus, in-depth know...

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Publicat a:Cells
Autors principals: Miranda-Gonçalves, Vera, Lameirinhas, Ana, Macedo-Silva, Catarina, Lobo, João, C. Dias, Paula, Ferreira, Verónica, Henrique, Rui, Jerónimo, Carmen
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226526/
https://ncbi.nlm.nih.gov/pubmed/32340156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9041053
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