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The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II

The fluorination of lead-like compounds is a common tool in medicinal chemistry to alter molecular properties in various ways and with different goals. We herein present a detailed study of the binding of fluorinated benzenesulfonamides to human Carbonic Anhydrase II by complementing macromolecular...

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Bibliografiske detaljer
Udgivet i:Biomolecules
Main Authors: Glöckner, Steffen, Ngo, Khang, Wagner, Björn, Heine, Andreas, Klebe, Gerhard
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226267/
https://ncbi.nlm.nih.gov/pubmed/32230853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10040509
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