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Lithium Chloride and GSK3 Inhibition Reduce Aquaporin-2 Expression in Primary Cultured Inner Medullary Collecting Duct Cells Due to Independent Mechanisms

Lithium chloride (LiCl) is a widely used drug for the treatment of bipolar disorders, but as a side effect, 40% of the patients develop diabetes insipidus. LiCl affects the activity of the glycogen synthase kinase 3 (GSK3), and mice deficient for GSK3β showed a reduction in the urine concentration c...

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Bibliografiske detaljer
Udgivet i:Cells
Main Authors: Kaiser, Marc, Edemir, Bayram
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226097/
https://ncbi.nlm.nih.gov/pubmed/32340354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9041060
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