BRCA1 Promoter Hypermethylation is Associated with Good Prognosis and Chemosensitivity in Triple-Negative Breast Cancer

The aberrant hypermethylation of BRCA1 promoter CpG islands induces the decreased expression of BRCA1 (Breast Cancer 1) protein. It can be detected in sporadic breast cancer without BRCA1 pathogenic variants, particularly in triple-negative breast cancers (TNBC). We investigated BRCA1 hypermethylati...

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Détails bibliographiques
Publié dans:Cancers (Basel)
Auteurs principaux: Jacot, William, Lopez-Crapez, Evelyne, Mollevi, Caroline, Boissière-Michot, Florence, Simony-Lafontaine, Joelle, Ho-Pun-Cheung, Alexandre, Chartron, Elodie, Theillet, Charles, Lemoine, Antoinette, Saffroy, Raphael, Lamy, Pierre-Jean, Guiu, Séverine
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225997/
https://ncbi.nlm.nih.gov/pubmed/32235500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12040828
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