BRCA1 Promoter Hypermethylation is Associated with Good Prognosis and Chemosensitivity in Triple-Negative Breast Cancer

The aberrant hypermethylation of BRCA1 promoter CpG islands induces the decreased expression of BRCA1 (Breast Cancer 1) protein. It can be detected in sporadic breast cancer without BRCA1 pathogenic variants, particularly in triple-negative breast cancers (TNBC). We investigated BRCA1 hypermethylati...

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Bibliografske podrobnosti
izdano v:Cancers (Basel)
Main Authors: Jacot, William, Lopez-Crapez, Evelyne, Mollevi, Caroline, Boissière-Michot, Florence, Simony-Lafontaine, Joelle, Ho-Pun-Cheung, Alexandre, Chartron, Elodie, Theillet, Charles, Lemoine, Antoinette, Saffroy, Raphael, Lamy, Pierre-Jean, Guiu, Séverine
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225997/
https://ncbi.nlm.nih.gov/pubmed/32235500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12040828
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