Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice

Numerous mutational studies have demonstrated that circadian clock proteins regulate behavior and metabolism. Nr1d1(Rev-erbα) is a key regulator of circadian gene expression and a pleiotropic regulator of skeletal muscle homeostasis and lipid metabolism. Loss of Rev-erbα expression induces muscular...

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Bibliographic Details
Published in:PLoS One
Main Authors: Welch, Ryan D., Billon, Cyrielle, Kameric, Amina, Burris, Thomas P., Flaveny, Colin A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224546/
https://ncbi.nlm.nih.gov/pubmed/32407314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227720
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