Methylnaltrexone for the treatment of opioid-induced constipation and gastrointestinal stasis in intensive care patients. Results from the MOTION trial

PURPOSE: Constipation can be a significant problem in critically unwell patients, associated with detrimental outcomes. Opioids are thought to contribute to the mechanism of bowel dysfunction. We tested if methylnaltrexone, a pure peripheral mu-opioid receptor antagonist, could reverse opioid-induce...

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Bibliographische Detailangaben
Veröffentlicht in:Intensive Care Med
Hauptverfasser: Patel, Parind B., Brett, Stephen J., O’Callaghan, David, Anjum, Aisha, Cross, Mary, Warwick, Jane, Gordon, Anthony C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7223905/
https://ncbi.nlm.nih.gov/pubmed/32016532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00134-019-05913-6
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