Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells

Estrogen (E2) is a major risk factor for the initiation and progression of malignancy in estrogen receptor (ER) positive breast cancers, whereas sirtuin 3 (Sirt3), a major mitochondrial NAD(+)-dependent deacetylase, has the inhibitory effect on the tumorigenic properties of ER positive MCF-7 breast...

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Publicat a:Antioxidants (Basel)
Autors principals: Pinterić, Marija, Podgorski, Iva I., Hadžija, Marijana Popović, Filić, Vedrana, Paradžik, Mladen, Proust, Bastien Lucien Jean, Dekanić, Ana, Ciganek, Ivan, Pleše, Denis, Marčinko, Dora, Balog, Tihomir, Sobočanec, Sandra
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7222218/
https://ncbi.nlm.nih.gov/pubmed/32244715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9040294
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