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Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells
Estrogen (E2) is a major risk factor for the initiation and progression of malignancy in estrogen receptor (ER) positive breast cancers, whereas sirtuin 3 (Sirt3), a major mitochondrial NAD(+)-dependent deacetylase, has the inhibitory effect on the tumorigenic properties of ER positive MCF-7 breast...
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| Publicado en: | Antioxidants (Basel) |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7222218/ https://ncbi.nlm.nih.gov/pubmed/32244715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9040294 |
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