PCSK9 Regulates Nox2-Mediated Platelet Activation via CD36 Receptor in Patients with Atrial Fibrillation

Background: High levels of proprotein convertase subtilisin/kexin 9 (PCSK9) is predictive of cardiovascular events (CVEs) in atrial fibrillation (AF). We hypothesized that PCSK9 may directly induce platelet activation (PA). Methods: We measured platelet aggregation, recruitment, Thromboxane B2 (TxB2...

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Udgivet i:Antioxidants (Basel)
Main Authors: Cammisotto, Vittoria, Pastori, Daniele, Nocella, Cristina, Bartimoccia, Simona, Castellani, Valentina, Marchese, Cinzia, Sili Scavalli, Antonio, Ettorre, Evaristo, Viceconte, Nicola, Violi, Francesco, Pignatelli, Pasquale, Carnevale, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7222182/
https://ncbi.nlm.nih.gov/pubmed/32252393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9040296
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