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Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone

Understanding the in vivo fate of vaccine antigens and adjuvants and their safety is crucial for the rational design of mucosal subunit vaccines. Prime and pull vaccination using the T helper 17-inducing adjuvant CAF01 administered parenterally and mucosally, respectively, has previously been sugges...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Thakur, Aneesh, Pinto, Fernanda Endringer, Hansen, Harald Severin, Andersen, Peter, Christensen, Dennis, Janfelt, Christian, Foged, Camilla
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7221191/
https://ncbi.nlm.nih.gov/pubmed/32457748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00803
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