Smad2/4 Signaling Pathway Is Critical for Epidermal Langerhans Cell Repopulation Under Inflammatory Condition but Not Required for Their Homeostasis at Steady State

Epidermal Langerhans cells (LCs) are skin-resident dendritic cells that are essential for the induction of skin immunity and tolerance. Transforming growth factor-β 1 (TGFβ1) is a crucial factor for LC maintenance and function. However, the underlying TGFβ1 signaling pathways remain unclear. Our pre...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Huang, Linting, Li, Gui-Hua, Yu, Qian, Xu, Yingping, Cvetkovski, Steven, Wang, Xuan, Parajuli, Nirmal, Udo-Inyang, Imo, Kaplan, Daniel, Zhou, Li, Yao, Zhirong, Mi, Qing-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7221176/
https://ncbi.nlm.nih.gov/pubmed/32457763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00912
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