Virtual Screening and Optimization of Novel mTOR Inhibitors for Radiosensitization of Hepatocellular Carcinoma

BACKGROUND: Radiotherapy has an ameliorative effect on a wide variety of tumors, but hepatocellular carcinoma (HCC) is insensitive to this treatment. Overactivated mammalian target of rapamycin (mTOR) plays an important part in the resistance of HCC to radiotherapy; thus, mTOR inhibitors have potent...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Feng, Ying-Qi, Gu, Shuang-Xi, Chen, Yong-Shou, Gao, Xu-Dong, Ren, Yi-Xin, Chen, Jian-Chao, Lu, Yin-Ying, Zhang, Heng, Cao, Shuang
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220363/
https://ncbi.nlm.nih.gov/pubmed/32440103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S249156
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