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Inhibition of natriuretic peptide receptor 1 reduces itch in mice

There is a major clinical need for new therapies for treatment of chronic itch. Many of the molecular components involved in itch neuro-transmission are known including the neuropeptide NPPB, a transmitter required for normal itch responses to multiple pruritogens in mice. Here we investigated the p...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Solinski, Hans Jürgen, Dranchak, Patricia, Oliphant, Erin, Gu, Xinglong, Earnest, Thomas W., Braisted, John, Inglese, James, Hoon, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218920/
https://ncbi.nlm.nih.gov/pubmed/31292265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav5464
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