Development of an anti-human complement C6 monoclonal antibody that inhibits the assembly of membrane attack complexes

Membrane attack complexes (MACs; C5b-9) assembled after complement activation can directly injure self-tissues, leading to various diseases. Eculizumab, a monoclonal antibody (mAb) against complement component C5, is being used in the clinic to treat diseases in which MAC-mediated tissue damage is a...

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Publicat a:Blood Adv
Autors principals: Lin, Kimberly, Zhang, Lingjun, Kong, Michael, Yang, Maojing, Chen, Yinghua, Poptic, Earl, Hoffner, Melanie, Xu, Jijun, Tam, Connie, Lin, Feng
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2020
Matèries:
Red Cells, Iron, and Erythropoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218433/
https://ncbi.nlm.nih.gov/pubmed/32396613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001690
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