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Development of an anti-human complement C6 monoclonal antibody that inhibits the assembly of membrane attack complexes
Membrane attack complexes (MACs; C5b-9) assembled after complement activation can directly injure self-tissues, leading to various diseases. Eculizumab, a monoclonal antibody (mAb) against complement component C5, is being used in the clinic to treat diseases in which MAC-mediated tissue damage is a...
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| 出版年: | Blood Adv |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7218433/ https://ncbi.nlm.nih.gov/pubmed/32396613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001690 |
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