Modelling hepatitis D virus RNA and HBsAg dynamics during nucleic acid polymer monotherapy suggest rapid turnover of HBsAg

Hepatitis D virus (HDV) requires hepatitis B surface antigen (HBsAg) for its assembly and release. Current HBV treatments are only marginally effective against HDV because they fail to inhibit HBsAg production/secretion. However, monotherapy with the nucleic acid polymer REP 2139-Ca is accompanied b...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Shekhtman, Louis, Cotler, Scott J., Hershkovich, Leeor, Uprichard, Susan L., Bazinet, Michel, Pantea, Victor, Cebotarescu, Valentin, Cojuhari, Lilia, Jimbei, Pavlina, Krawczyk, Adalbert, Dittmer, Ulf, Vaillant, Andrew, Dahari, Harel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217939/
https://ncbi.nlm.nih.gov/pubmed/32398799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64122-0
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