Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates CD4(+) T cells from lean, normogly...

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Vydáno v:Cell Metab
Hlavní autoři: Bharath, Leena P., Agrawal, Madhur, McCambridge, Grace, Nicholas, Dequina A., Hasturk, Hatice, Liu, Jing, Jiang, Kai, Liu, Rui, Guo, Zhenheng, Deeney, Jude, Apovian, Caroline M., Snyder-Cappione, Jennifer, Hawk, Gregory S., Fleeman, Rebecca M., Pihl, Riley M.F., Thompson, Katherine, Belkina, Anna C., Cui, Licong, Proctor, Elizabeth A., Kern, Philip A., Nikolajczyk, Barbara S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Inc. 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217133/
https://ncbi.nlm.nih.gov/pubmed/32402267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.04.015
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