Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development

Immunotherapy using immune checkpoint inhibitors (ICIs) induces durable responses in many metastatic cancers. Metastatic uveal melanoma (mUM), typically occurring in the liver, is one of the most refractory tumours to ICIs and has dismal outcomes. Monosomy 3 (M3), polysomy 8q, and BAP1 loss in prima...

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Publicat a:J Pathol
Autors principals: Figueiredo, Carlos R, Kalirai, Helen, Sacco, Joseph J, Azevedo, Ricardo A, Duckworth, Andrew, Slupsky, Joseph R, Coulson, Judy M, Coupland, Sarah E
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2020
Matèries:
Original Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216965/
https://ncbi.nlm.nih.gov/pubmed/31960425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5384
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