Defective Regulation of Membrane TNFα Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells

Besides an antigen-presenting function and ability to induce antitumor immune responses, dendritic cells (DCs) possess a direct tumoricidal activity. We previously reported that monocyte-derived IFNα-induced DCs (IFN-DCs) of glioblastoma multiforme patients express low levels of membrane TNFα molecu...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Tyrinova, Tamara, Leplina, Olga, Mishinov, Sergey, Tikhonova, Marina, Dolgova, Evgeniya, Proskurina, Anastasiya, Stupack, Vyacheslav, Bogachev, Sergey, Ostanin, Alexander, Chernykh, Elena
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7215742/
https://ncbi.nlm.nih.gov/pubmed/32326230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21082898
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