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Structural Characterization of Carbonic Anhydrase VIII and Effects of Missense Single Nucleotide Variations to Protein Structure and Function
Human carbonic anhydrase 8 (CA-VIII) is an acatalytic isoform of the [Formula: see text]-CA family. Though the protein cannot hydrate CO(2), CA-VIII is essential for calcium (Ca(2+)) homeostasis within the body, and achieves this by allosterically inhibiting the binding of inositol 1,4,5-triphosphat...
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| Publicado no: | Int J Mol Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7215520/ https://ncbi.nlm.nih.gov/pubmed/32316137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21082764 |
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