FtH-Mediated ROS Dysregulation Promotes CXCL12/CXCR4 Axis Activation and EMT-Like Trans-Differentiation in Erythroleukemia K562 Cells

The cell-microenvironment communication is essential for homing of hematopoietic stem cells in stromal niches. Recent evidences support the involvement of epithelial-to-mesenchymal (EMT) process in hematopoietic stem cell homeostasis as well as in leukemia cells invasiveness and migration capability...

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Veröffentlicht in:Front Oncol
Hauptverfasser: Chirillo, Roberta, Aversa, Ilenia, Di Vito, Anna, Salatino, Alessandro, Battaglia, Anna Martina, Sacco, Alessandro, Di Sanzo, Maddalena Adriana, Faniello, Maria Concetta, Quaresima, Barbara, Palmieri, Camillo, Biamonte, Flavia, Costanzo, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214836/
https://ncbi.nlm.nih.gov/pubmed/32432042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00698
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