Long-Lasting Rituximab-Induced Reduction of Specific—But Not Total—IgG4 in MuSK-Positive Myasthenia Gravis

The use of rituximab (RTX), an anti-CD20 monoclonal antibody (Ab), in refractory myasthenia gravis (MG) is associated with a better response in patients with Abs to the muscle-specific tyrosine kinase (MuSK) than in other MG subgroups. Anti-MuSK Abs are mostly IgG4 with proven pathogenicity and posi...

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Publicado en:Front Immunol
Autores principales: Marino, Mariapaola, Basile, Umberto, Spagni, Gregorio, Napodano, Cecilia, Iorio, Raffaele, Gulli, Francesca, Todi, Laura, Provenzano, Carlo, Bartoccioni, Emanuela, Evoli, Amelia
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214629/
https://ncbi.nlm.nih.gov/pubmed/32431692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00613
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