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Physiological levels of the PTEN-PI3K-AKT axis activity are required for maintenance of Burkitt lymphoma
In addition to oncogenic MYC translocations, Burkitt lymphoma (BL) depends on the germinal centre (GC) dark zone (DZ) B cell survival and proliferation programme, which is characterized by relatively low PI3K-AKT activity. Paradoxically, PI3K-AKT activation facilitates MYC-driven lymphomagenesis in...
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| Publicado no: | Leukemia |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7214272/ https://ncbi.nlm.nih.gov/pubmed/31719683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0628-0 |
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