ML264 inhibits osteosarcoma growth and metastasis via inhibition of JAK2/STAT3 and WNT/β‐catenin signalling pathways

Osteosarcoma, the most common bone malignancy, has a high morbidity rate and poor prognosis. Krüppel‐like factor 5 (KLF5) is a key transcriptional regulator of cellular proliferation whose overexpression is observed in osteosarcoma cell lines (U2OS, 143B, MG63 and SAOS2). ML264, a small‐molecule inh...

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Pubblicato in:J Cell Mol Med
Autori principali: Huang, Hai, Han, Ying, Chen, Zhijun, Pan, Xin, Yuan, Putao, Zhao, Xiangde, Zhu, Hongfang, Wang, Jiying, Sun, Xuewu, Shi, Peihua
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214147/
https://ncbi.nlm.nih.gov/pubmed/32285603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15226
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