Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules

Sodium glucose cotransporter 2 (SGLT2) inhibitors are beneficial in halting diabetic kidney disease; however, the complete mechanisms have not yet been elucidated. The epithelial-mesenchymal transition (EMT) is associated with the suppression of sirtuin 3 (Sirt3) and aberrant glycolysis. Here, we hy...

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Опубликовано в: :JCI Insight
Главные авторы: Li, Jinpeng, Liu, Haijie, Takagi, Susumu, Nitta, Kyoko, Kitada, Munehiro, Srivastava, Swayam Prakash, Takagaki, Yuta, Kanasaki, Keizo, Koya, Daisuke
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2020
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213787/
https://ncbi.nlm.nih.gov/pubmed/32134397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129034
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