Antibody-Dependent Enhancement of Severe Disease Is Mediated by Serum Viral Load in Pediatric Dengue Virus Infections

BACKGROUND: Low preexisting anti-dengue virus (DENV) antibody levels are associated with elevated disease severity. While antibody-dependent enhancement of dengue is thought to be driven by viral load, this has not been conclusively shown. We evaluated the association between preinfection anti-DENV...

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Veröffentlicht in:J Infect Dis
Hauptverfasser: Waggoner, Jesse J, Katzelnick, Leah C, Burger-Calderon, Raquel, Gallini, Julia, Moore, Renee H, Kuan, Guillermina, Balmaseda, Angel, Pinsky, Benjamin A, Harris, Eva
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213574/
https://ncbi.nlm.nih.gov/pubmed/32236481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiz618
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