Metformin limits osteoarthritis development and progression through activation of AMPK signalling

OBJECTIVES: In this study, we aim to determine the effect of metformin on osteoarthritis (OA) development and progression. METHODS: Destabilisation of the medial meniscus (DMM) surgery was performed in 10-week-old wild type and AMP-activated protein kinase (AMPK)α1 knockout (KO) mice. Metformin (4 m...

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Bibliographic Details
Published in:Ann Rheum Dis
Main Authors: Li, Jun, Zhang, Bin, Liu, Wei-Xiao, Lu, Ke, Pan, Haobo, Wang, Tingyu, Oh, Chun-do, Yi, Dan, Huang, Jian, Zhao, Lan, Ning, Guangzhi, Xing, Cong, Xiao, Guozhi, Liu-Bryan, Ru, Feng, Shiqing, Chen, Di
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2020
Subjects:
Osteoarthritis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213329/
https://ncbi.nlm.nih.gov/pubmed/32156705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2019-216713
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