Dual neutralisation of interleukin-17A and interleukin-17F with bimekizumab in patients with active ankylosing spondylitis: results from a 48-week phase IIb, randomised, double-blind, placebo-controlled, dose-ranging study

OBJECTIVES: Bimekizumab selectively neutralises both interleukin (IL)-17A and IL-17F. We report efficacy and safety in a phase IIb dose-ranging study in patients with active ankylosing spondylitis (AS). METHODS: Adults with AS (fulfilling modified New York criteria) were randomised 1:1:1:1:1 to bime...

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Vydáno v:Ann Rheum Dis
Hlavní autoři: van der Heijde, Désirée, Gensler, Lianne S, Deodhar, Atul, Baraliakos, Xenofon, Poddubnyy, Denis, Kivitz, Alan, Farmer, Mary Katherine, Baeten, Dominique, Goldammer, Nadine, Coarse, Jason, Oortgiesen, Marga, Dougados, Maxime
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2020
Témata:
Spondyloarthritis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213320/
https://ncbi.nlm.nih.gov/pubmed/32253184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2020-216980
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