Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients

OBJECTIVES: Genome-wide meta-analyses of clinically defined gout were performed to identify subtype-specific susceptibility loci. Evaluation using selection pressure analysis with these loci was also conducted to investigate genetic risks characteristic of the Japanese population over the last 2000–...

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Publicado en:Ann Rheum Dis
Autores principales: Nakayama, Akiyoshi, Nakatochi, Masahiro, Kawamura, Yusuke, Yamamoto, Ken, Nakaoka, Hirofumi, Shimizu, Seiko, Higashino, Toshihide, Koyama, Teruhide, Hishida, Asahi, Kuriki, Kiyonori, Watanabe, Miki, Shimizu, Toru, Ooyama, Keiko, Ooyama, Hiroshi, Nagase, Mitsuo, Hidaka, Yuji, Matsui, Daisuke, Tamura, Takashi, Nishiyama, Takeshi, Shimanoe, Chisato, Katsuura-Kamano, Sakurako, Takashima, Naoyuki, Shirai, Yuya, Kawaguchi, Makoto, Takao, Mikiya, Sugiyama, Ryo, Takada, Yuzo, Nakamura, Takahiro, Nakashima, Hiroshi, Tsunoda, Masashi, Danjoh, Inaho, Hozawa, Atsushi, Hosomichi, Kazuyoshi, Toyoda, Yu, Kubota, Yu, Takada, Tappei, Suzuki, Hiroshi, Stiburkova, Blanka, Major, Tanya J., Merriman, Tony R., Kuriyama, Nagato, Mikami, Haruo, Takezaki, Toshiro, Matsuo, Keitaro, Suzuki, Sadao, Hosoya, Tatsuo, Kamatani, Yoichiro, Kubo, Michiaki, Ichida, Kimiyoshi, Wakai, Kenji, Inoue, Ituro, Okada, Yukinori, Shinomiya, Nariyoshi, Matsuo, Hirotaka
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2020
Materias:
Crystal Arthropathies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213308/
https://ncbi.nlm.nih.gov/pubmed/32238385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2019-216644
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