ML-03 RECONSIDERATION OF TREATMENT FOR ELDERLY PATIENTS WITH PRIMARY CENTRAL NERVE SYSTEM LYMPHOMAS

BACKGROUND: The therapeutic response to high-dose methotrexate therapy (HD-MTX) for primary central nervous system lymphoma (PCNSL) varies. Polyglutamylation (PG) is a reversible protein modification, tumor cells show frequent occurrence of PG. Intracellularly polyglutamylated MTX is not subject to...

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Bibliographic Details
Published in:Neurooncol Adv
Main Authors: Shinojima, Naoki, Fujimoto, Kenji, Makino, Keishi, Yamamoto, Takahiro, Kuroda, Jun-ichiro, Ohta, Kazutaka, Takezaki, Tatsuya, Oda, Kazutaka, Nakamura, Kazumi, Jono, Hiroshi, Mikami, Yoshiki, Mukasa, Akitake
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213235/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz039.146
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