THER-01. PRECLINICAL DEVELOPMENT OF EO1001, A NOVEL IRREVERSIBLE BRAIN PENETRATING PAN-ErbB INHIBITOR

Dysregulation of ErbB-mediated signaling is observed in up to 90% of solid tumors. ErbB family cross-talk is implicated in the development of resistance and metastasis, including CNS metastases. Inhibition of multiple ErbB receptors may result in improved patient outcomes. EO1001 is a novel, patente...

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Vydáno v:Neurooncol Adv
Hlavní autoři: Shen, Wang, Bacha, Jeffrey, Brown, Dennis, Kanekal, Sarath, Sankar, Neil, Wang, ZhenZhong, Pedersen, Harry, Butowski, Nicholas, Nicolaides, Theodore, Sarkaria, Jann, James, C David, Giles, Francis
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213116/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz014.044
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