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Pleiotropy-Based Decomposition of Genetic Risk Scores: Association and Interaction Analysis for Type 2 Diabetes and CAD
Genetic risk for a disease in the population may be represented as a genetic risk score (GRS) constructed as the sum of inherited risk alleles, weighted by allelic effects established in an independent population. While this formulation captures overall genetic risk, it typically does not address ri...
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| Udgivet i: | Am J Hum Genet |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7212269/ https://ncbi.nlm.nih.gov/pubmed/32302534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2020.03.011 |
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