High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

Toward the goal of increasing the throughput of high-resolution mass characterization of intact antibodies, we developed a RapidFire–mass spectrometry (MS) assay using electrospray ionization. We achieved unprecedented screening throughput as fast as 15 s/sample, which is an order of magnitude impro...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Sawyer, William S., Srikumar, Neha, Carver, Joseph, Chu, Phillip Y., Shen, Amy, Xu, Ankai, Williams, Ambrose J., Spiess, Christoph, Wu, Cong, Liu, Yichin, Tran, John C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7211930/
https://ncbi.nlm.nih.gov/pubmed/32327606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917383117
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