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Protective role of endothelial calpain knockout in lipopolysaccharide-induced acute kidney injury via attenuation of the p38-iNOS pathway and NO/ROS production

To explore the role of calpain and its signaling pathway in lipopolysaccharide (LPS)-induced acute kidney injury (AKI), animal models of endotoxemia were established by administration of LPS to mice with endothelial-specific Capn4 knockout (TEK/Capn4(−/−)), mice with calpastatin (an endogenous calpa...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Liu, Zhifeng, Ji, Jingjing, Zheng, Dong, Su, Lei, Peng, Tianqing, Tang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210976/
https://ncbi.nlm.nih.gov/pubmed/32346126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-020-0426-9
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